Scientist - Tissue Clearing and 3D Image Analysis

About Deep Piction

Deep Piction is a pioneering biotechnology firm located in Munich specializing in cutting-edge tissue clearing, 3D imaging, spatial biology, and AI technologies that aid in expediting drug discovery and therapeutic innovation. Their work integrates whole-organ and whole-body imaging at single-cell resolution alongside quantitative image analysis, spatial molecular profiling, and artificial intelligence. These technologies support internal drug development projects and collaborations with pharmaceutical and biotech partners.

Role Overview

This hands-on scientific position focuses on driving and enabling projects to develop, standardize, and expand workflows related to tissue clearing, light-sheet microscopy, and quantitative image analysis. The candidate will manage tissue-clearing and 3D imaging assignments, collaborate closely with experimental, computational, and commercial teams, and transform complex biological specimens into robust quantitative data.

Key Responsibilities

• Lead tissue clearing and 3D imaging projects supporting internal research and external partnerships.
• Design and perform whole-organ and whole-body tissue clearing, staining, imaging, and analytical protocols.
• Operate and enhance light-sheet microscopy processes and infrastructure.
• Assist in quantitative image analysis, visualization, atlas alignment, and biological data interpretation.
• Collaborate with AI specialists to create scalable image-analysis pipelines and automation solutions.
• Refine protocols, quality control measures, documentation, reproducibility, and throughput capabilities.
• Coordinate cross-functional projects involving experimental, imaging, AI, and therapeutic development teams.
• Train and mentor junior researchers and technical personnel.
• Participate in authoring scientific reports, presentations, publications, patents, and technology development activities.
• Optionally assist with animal study planning and compliances.

Qualifications and Experience

• Master's or PhD in life sciences, biomedical engineering, optical physics, neuroscience, bioengineering, or related disciplines.
• Proven experience in tissue clearing, fluorescence microscopy, 3D histology, or whole-mount imaging techniques.
• Practical expertise in light-sheet microscopy and large-volume biological image acquisition.
• Familiarity with Imaris and/or arivis Vision4D software.
• Knowledge of BigStitcher or similar tools for data stitching and processing of large datasets.
• Competence in atlas registration, cell detection, segmentation, and quantitative analysis of cleared tissue samples.
• Strong independent planning, execution, troubleshooting, and documentation skills for complex experiments.
• Excellent organizational skills to manage multiple projects and collaborations simultaneously.
• Fluent in scientific English with effective communication skills across experimental and computational teams.

Preferred Additional Skills

• Experience with Fiji/ImageJ, Python-based image processing, napari visualization, automation, or batch processing pipelines.
• Background in machine learning or deep learning for image analysis.
• Expertise in whole-organ or whole-body imaging datasets.
• Knowledge of antibody labeling, whole-mount immunostaining, tissue expansion, or spatial molecular profiling.
• Experience with quality assurance, protocol standardization, or working in biotech/pharmaceutical environments.
• FELASA B certification, animal study coordination, or regulatory documentation experience.
• Use of VR-based annotation or 3D proofreading tools.
• Supervision of students, technicians, or junior researchers.

Employment Details and Benefits

• Access to advanced technologies in tissue clearing, whole-body imaging, and AI.
• Work with unique 3D cellular-resolution datasets spanning various therapeutic areas.
• Direct involvement in pharmaceutical collaborations and internal drug development initiatives.
• Collaborate with interdisciplinary teams across biology, imaging, AI, data science, and business development.
• Opportunity to influence and scale pivotal scientific workflows in a growing biotech company.
• Dynamic, international, and interdisciplinary work environment based in Munich.
• Full-time, onsite role with competitive salary reflecting experience and qualifications.
• Flexible starting date, ideally as soon as possible.

Application Guidelines

• Submit a singular PDF file combining your CV, a cover letter, and a detailed summary of relevant experience in tissue clearing, light-sheet microscopy, 3D image analysis, and project management.
• Do not send additional supporting documents (certificates, references, letters, publications) at this initial stage.
• Your application will be reviewed on a rolling basis until the vacancy is filled.